Initial Success Achieved in Ending Surgical Castration of Swine



  • Advanced Animal Systems

Importance of Breakthrough

Male piglets are castrated to improve the quality of meat for consumers, but this practice is also a concerning animal welfare issue, as it is usually performed without pain management. Recombinetics/Acceligen and Hendrix Genetics successfully used a genome editing method to create swine that remain in a pre-pubertal state, thus eliminating the need for surgical castration. The first litter of castration-free prototype piglets using commercially relevant genetics confirms the methodology is working.

Details about this breakthrough

Intact male pigs experience “boar taint,” which causes an unpleasant odor and unsavory taste in the resulting meat. Male pigs are castrated young to prevent boar taint; pain relievers are rarely administered. Castrated piglets show an acute physiological stress response to castration, including increased stress hormone levels, elevated heart rate and demonstrated indicators of pain that can last for four days following the procedure. The European Union has banned the practice of swine castration, but its implementation has been delayed amid challenges to the costs of implementation.

This project has successfully deleted the gene that triggers the release of hormones necessary for sexual maturation in the piglets’ DNA, preventing them from reaching puberty and thus negating the need to castrate the pigs. The next step in this research is determining the commercial viability of castration-free pigs. Since these prototype pigs were created to be permanently prepubescent, the alliance is determining how to breed these pigs without comprising traits like feed efficiency and meat quality. The alliance comprises some of the largest pig genetic companies in the world, possessing the capacity and capabilities needed to supply these permanently prepubescent pigs to pork producers worldwide.

The birth of these castration-free prototype piglets using commercially relevant genetics is just another example of how Acceligen is working to deploy our breeding technologies to help producers better meet the demands of consumers and producers to improve food animal well-being. The technical expertise and support provided by Hypor and the Foundation for Food & Agriculture Research gives our alliance the capability to meet these demands with the highest standards. Together we will bring the castration-free trait to market and provide solutions to benefit the pork industry. Dr. Tad Sonstegard
Chief Executive and Scientific Officer of Acceligen, Recombinetics’ agriculture division.



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