Limousin cattle breed cow with cattle

ICASA Seeks Research to Examine and Treat Liver Abscesses in Beef Cattle

The International Consortium for Antimicrobial Stewardship in Agriculture (ICASA) is soliciting concepts for animal health research that accelerates antibiotic stewardship across the livestock supply chain.

Liver abscesses, a condition caused by bacteria crossing from an animal’s gastrointestinal tract into the bloodstream and accumulating in the liver, affect roughly 20 percent of U.S. beef cattle, although the incidence can be as high as 70 percent in some groups. The conditionis associated with reduced feed efficiency and greater trimming at harvest, negatively impacting industry profitability. Animal scientists and veterinarians do not fully understand how liver abscesses form and why incidence varies under different scenarios.

ICASA is seeking letters of intent (LOI) for research supporting one of the following knowledge areas:

  1. increased understanding of liver abscess pathobiology,
  2. development of new models and
  3. epidemiology and incidence.

Additionally, ICASA is also seeking diagnostic tools or technologies that enable informed decision-making regarding metaphylactic treatment, a practice in which a group of animals is treated at the same time to prevent the disease from spreading and affecting many animals.LOIs should be relevant to commercial production systems, breeds and management practices in the U.S..

ICASA encourages applicants to collaborate with commercial livestock producers, processors and allied industry. Applicants should also describe how the work will enhance responsible antibiotic use, reduce the potential for resistance and/or provide actionable information to antimicrobial-prescribers.

As ICASA’s call for research concepts was developed in collaboration with representatives of the beef cattle industry, it speaks to the sector’s research needs related to antibiotic stewardship. Developing new interventions for animal health challenges requires fundamental research. Tim Kurt, DVM
Scientific Program Director, October 2016- September 2022
Advanced Animal Systems

LOI submissions are due on July 27, 2022. ICASA anticipates awarding multiple awards totaling approximately $1 million to $2 million through this funding opportunity with a maximum of $300,000 available per project. For more information about this funding opportunity, visit the 2022 ICASA LOI Open Opportunity webpage.

ICASA welcomes applications from all domestic and international higher education institutions, nonprofit and for-profit organizations and government-affiliated research agencies.

FFAR established ICASA in 2019 with an initial $7.5 million investment to fund research that promotes targeted antibiotic use, advances animal health and welfare and increases transparency in food production practices. The private sector is matching FFAR’s investment for a total $15 million investment in antibiotic stewardship research.


Foundation for Food & Agriculture Research

The Foundation for Food & Agriculture Research (FFAR) builds public-private partnerships to fund bold research addressing big food and agriculture challenges. FFAR was established in the 2014 Farm Bill to increase public agriculture research investments, fill knowledge gaps and complement the U.S. Department of Agriculture’s research agenda. FFAR’s model matches federal funding from Congress with private funding, delivering a powerful return on taxpayer investment. Through collaboration and partnerships, FFAR advances actionable science benefiting farmers, consumers and the environment.


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